Tramadol, a prescription painkiller, is an opioid medication that works by binding to the brain's opiate receptors and blocking the effects of natural opioids like endorphins. It can be used for moderate to severe pain. Tramadol is available in immediate-release (IR) and extended-release (ER) forms.


Tramadol is a prescription painkiller used for moderate to severe pain. The drug was approved by the FDA in 1995 and prescribed since then. It is available in generic form and comes in both immediate-release and extended-release forms.


What is tramadol used to treat?


Tramadol used to treat such as:

  • Pain

  • Anxiety

  • Depression

  • Nausea


How does it work?


The active ingredient in tramadol is called tramadol hydrochloride. When you take this pill, your body absorbs it into your bloodstream. This allows the medicine to reach its target site in your brain. In your brain, tramadol binds with opioid receptors. These are particular sites on nerve cells where neurotransmitters, chemicals that transmit messages between nerves, bind. Opioid receptors are part of the brain's reward system. They help control feelings of pleasure and relieve pain. By blocking these receptors, tramadol stops the feeling.

Tramadol is a prescribed drug used to treat moderate to severe pain. It is also used for treating some types of cancer pain. The most prevalent adverse effects are nausea, vomiting, constipation, dizziness, sleepiness, dry mouth, headache, perspiration, weakness, and weariness.


How long does tramadol take to work?


Tramadol works within 30 minutes after you swallow it. You should not take more than one dose per day. If you need two doses, wait at least 6 hours before taking the second dose. Do not stop taking tramadol without first talking to your doctor. Stopping too soon may cause withdrawal symptoms.


When should I not use tramadol?


Do not take tramadol if you have taken another narcotic or opioid pain reliever within 24 hours. Avoid using tramadol if you are allergic to any ingredients in the product. Tell your healthcare provider right away if you experience shortness of breath, chest tightness, wheezing, swelling.


Tramadol works fast, with symptoms usually starting within 15 minutes and reaching their peak effect after 30-60 minutes. For many people, relief begins within 2 hours of taking the first dose and lasts between 4 -6 hours.


If you need more relief from your pain, you can take another dose after that period. However, it may take up to 4 hours to kick in. The effects of tramadol last between 2 and 6 hours.


Is there any evidence that tramadol can be addictive?


Tramadol can be addictive, especially when mixed with alcohol or other medications containing codeine. Use as directed.


Tramadol can interact with other medications. Some drugs can make tramadol less effective. Talk to your pharmacist about which ones you should avoid while taking tramadol. Some examples of these drugs are:

  • Alcohol

  • Certain Antibiotics

  • Cimetidine (Tagamet)

  • Clonazepam (Klonopin)

  • Cyclosporine (Neoral)

  • Diltiazem (Cardizem CD)


There have been no cases of tramadol addiction. However, if you take this medication for more than three months, your doctor should monitor you closely. Consult your doctor right away if you are concerned about probable misuse or addiction.


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