A systematic review is designed to summarise the results of available studies and provides a high level of evidence-based findings on the effectiveness of interventions. Our experts can handle any type of research, whether you need systematic review based on controlled clinical trials or review based on observational study designs or community (e.g. psychology) intervention? Our experts at Pubrica, perform a rigorous systematic review by following multi-step process, which includes


(a) Identifying a well-focused clinically relevant research question while following suitable frameworks including PICO, SPICE, SPIDER, and ECLIPSE etc.

(b) Developing a detailed review protocol with strict inclusion and exclusion criteria and registering the protocol at different registries such as The Campbell Collaboration, The Cochrane Collaboration, OSF Preregistration, SYREAF-systematic reviews for animals and food, Research Registry, Joanna Briggs Institute (JBI) and PROSPERO.

(c) A systematic literature search of multiple databases (includes PubMed, Embase, MEDLINE, Web of Science, and Google Scholar) in finding relevant references that further requires extensive search and study. A number of other electronic databases and bibliographic sources will also be searched. Sources we posit for use for the project include:


  • Scientific literature databases as described above and others
  • Cochrane Library
  • Database of Abstracts of Reviews of Effectiveness (DARE)
  • NHS Economic Evaluation database
  • Material referenced in Publications obtained in the course of research on the topic
  • International Network of Agencies for Health Technology Assessment (INAHTA) documents
  • Clinical trials databases, including clinicaltrialsregister.eu (EU), clinicaltrials.gov (US) and others.


However, using multiple databases to search relevant studies is laborious and time-consuming so that a well-designed search strategy will be developed.

(d) Meticulous study identification using a variety of search terms, checking for a clear outcome (primary and secondary)

(e) Systematic data abstraction, by at least two sets of investigators independently,

(f) Risk of bias assessment with the use of existing different assessment tools (e.g. STROBE). For example, allocation concealment (selection bias), incomplete outcome data addressed (attrition bias), and selective reporting (reporting bias).

(g) Thoughtful quantitative synthesis through meta-analysis where relevant. Besides informing guidelines, credible systematic reviews and quality of evidence assessment can help identify key knowledge gaps for future studies.

We can help you with the most used qualitative systematic review, as well as, quantitative, health policy and management information and meta-analysis.

Our systematic review at Pubrica is more structured as at every stage of writing, and we ensure to critically check the rigour using standard methodological checklists such as PRISMA, CASP, AMSTAR, and ARIF etc., based on the checklist provided.

  • Further, the general structure is presented as follows:Formulate the research question
  • Search for studies
  • Selection of studies
  • Data collection
  • Methodological quality assessment
  • Methods used for presenting results
  • Findings are interpreted.
  • The time required for producing a quality systematic review


Our Experts:


Pubrica Healthcare and Medical Research Experts provide custom scientific research writing and analytics (data science & biostatistics) services that have a team of experienced researchers and writers who are available round the clock and ready to assist you with the systematic review writing. We have PhD level domain experts who also have decades of scientific writing experience. As such, we have the capability to deliver a high calibre, written literature review. Our experts are very facile around scientific literature databases to complete the literature review, including PubMed & Medline and cancer domain expertise to selectively identify impactful journal articles to draw upon for the review. Written status reports will be shared at every milestone completion including


1) an overview of the status of completion of deliverables including specifics of the literature search and environmental scans;

2) a description of progress addressing discrete components of the Report as agreed;

3) a description of challenges encountered, potential risks and associated mitigation strategy Systematic reviews are performed for synthesizing the evidence of multiple scientific investigations to answer a specific research question in a manner that is reproducible and transparent while seeking to include all published evidence on the topic followed by evaluating the quality of this evidence. A Systematic review remains among the best forms of evidence and reduces the bias inherent in other methods. In the disciplines of public policy health and health sciences, systematic reviews have become the main methodology. Previously, some have provided that structure research ought to embrace the systematic review, but limited guidance is available. This section presented an overview of the various steps involved in performing a systematic review. This information should provide proper guidance for those who are conducting a systematic literature review (Davis, 2019 ).

Key characteristics of the systematic review

  • Identification of a research question
  • Inclusion & exclusion criteria
  • Rigorous & systematic search of the literature
  • Critical appraisal of included studies
  • Data extraction and management
  • Analysis & interpretation of results
  • Report for publication


Different types of the systematic review

The systematic review is mainly classified into three types, including (1) meta-analysis, (2) quantitative analysis and (3) qualitative analysis.

Meta-analysis: A meta-analysis utilizes statistical methods to incorporate appraisals of impact from relevant studies that are independent yet comparable and outline them.

Quantitative: To combine the results of 2 or more studies by using statistical analysis is called quantitative analysis.

Qualitative: The qualitative analysis generally defined as the results of the relevant studies are summarized but not combined statistically.



The conclusion should be containing the summary of different aspects of the present study, and the results generated as well as the future scope of research and the findings derived from the present study.

Performing a systematic review of literature is quite complicated and time-consuming process which takes between 6 and 18 months on average depends on the study design. The guidelines mentioned above provide a good outline for conducting a systematic review of the literature. This framework especially is essential for early career researchers and medical students to enhance their writing knowledge on the systematic review of the literature.